cyclodextrin renal toxicity

    Adverse Effects of Voriconazole - Medscape

    Discussion. Occurrence of these ADEs seems to be multifactorial, and the relation with voriconazole is therefore difficult to assess. Nine cases of acute renal failure were reported; in 2 of these, intravenous voriconazole was administered. In clinical trials, acute renal failure was observed in 3.9% of patients,.

    Beta-Cyclodextrin - TabletWise

    Yes, acute rheumatic pain and osteoarthritis are among the most common reported uses for Beta-Cyclodextrin. Please do not use Beta-Cyclodextrin for acute rheumatic pain and osteoarthritis without consulting first with your doctor. Click here and view survey results to find out what other patients report as common uses for Beta-Cyclodextrin.

    Pharmacokinetics of sulfobutylether-β-cyclodextrin (SBECD .

    The disposition of sulfobutylether-β-cyclodextrin (SBECD), the solubilizing excipient in intravenous (IV) voriconazole, was assessed in seven male subjects with end-stage renal disease on hemodialysis and six subjects with normal renal function.

    Cyclodextrin Protects Podocytes in Diabetic Kidney Disease

    Induction of cholesterol efflux with cyclodextrin (CD) but not inhibition of cholesterol synthesis with simvastatin prevented podocyte injury observed in vitro after exposure to patient sera. Subcutaneous administration of CD to diabetic BTBR (black and tan, brachiuric) ob/ob mice was safe and reduced albuminuria, mesangial expansion, kidney weight, and cortical cholesterol content.

    Cyclodextrin News

    May 03, 2019· Ligand Pharmaceuticals Incorporated announced completion of enrollment of the Company's Phase 1 clinical trial of its internal Captisol-enabled (CE) Iohexol program. The CE-Iohexol program is designed to develop a Captisol-enabled, next-generation contrast agent for diagnostic imaging with a reduced risk of renal toxicity. Contrast agents are used to enhance diagnostic imaging.

    Piroxicam - FDA prescribing information, side effects and uses

    Aug 01, 2018· Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. In these patients, administration of an NSAID may cause a dose-dependent reduction in prostaglandin formation and, secondarily, in renal blood flow, which may precipitate overt renal decompensation.

    Effect of Cyclodextrin Infusion in a Rat Model of .

    Sulfobutylether-β-cyclodextrin (SBE-CD) is a pharmaceutical excipient known to bind verapamil. After intravenous administration, clearance of SBE-CD approximates glomerular filtration rate. We hypothesized that SBE-CD would complex with verapamil in vivo, enhance renal elimination, and increase time to death in a rat model of verapamil toxicity.

    Captisol-enabled Contrast Media with Reduced Renal .

    Jan 30, 2019· Captisol-enabled Contrast Media with Reduced Renal Toxicity in Development This case study was sponsored by Ligand Pharmaceuticals The medical imaging market relies heavily on contrast media, injected into patients to increase the contrast of bodily structures in images and improve diagnostic examinations.

    Therapeutic drug monitoring and safety of intravenous .

    Jun 21, 2016· Clinicians often avoid using intravenous voriconazole in patients with moderate to severe renal impairment [creatinine clearance (CrCl), <50 ml min −1] because they believe accumulation of the intravenous vehicle, cyclodextrin, may cause nephrotoxicity. 9, 10 However, recent studies have shown that a polysubstituted derivative of cyclodextrin used as an excipient for solubilisation of voriconazole, …

    Cyclodextrins - journals.sagepub

    β-cyclodextrin (β-CD) and other cyclodextrins (CDs) have utility for solubilizing and stabilizing drugs; however, some are nephrotoxic when . The renal toxicity of α-CD and β-CD after parenteral adminis-tration (Frank et al., 1976) as well as problems with a number

    Cyclodextrin News

    Jul 17, 2019· Ligand Pharmaceuticals Incorporated announced positive top line results from a Phase 1 clinical trial of its internal Captisol-enabled (CE) Iohexol program. The CE-Iohexol program was established in January 2018 to develop a Captisol-enabled, next-generation contrast agent for diagnostic imaging with a reduced risk of renal toxicity.

    Cyclodextrin News

    May 03, 2019· Contrast-induced acute kidney injury (CI-AKI) is the acute impairment of renal function following intravascular administration of an iodinated contrast agent, and occurs most frequently following coronary angiography, percutaneous coronary intervention and contrast-enhanced computed tomography, especially among patients at risk of renal injury such as those with advanced age, …

    Cyclodextrins - journals.sagepub

    β-cyclodextrin (β-CD) and other cyclodextrins (CDs) have utility for solubilizing and stabilizing drugs; however, some are nephrotoxic when administered parenterally. A number of workers have attempted to identify, prepare, and evaluate various CD derivatives with superior inclusion com-

    Beta-Cyclodextrin - an overview | ScienceDirect Topics

    Nov 09, 2010· Sulfobutylether β-cyclodextrin sodium accumulated in three patients with renal failure during intravenous administration of voriconazole; the maximum concentrations were 523 μg/ml in an 18-year-old man, 409 μg/ml in a 57-year-old man, and 581 μg/ml in a 47-year-old man.

    2-Hydroxypropyl-β-cyclodextrin (HP-β-CD): A toxicology .

    However, if β-cyclodextrin is administered at higher doses in animals via a subcutaneous route, it will cause a decrease in body weight gain, a decrease in liver weight, and nephrotoxicity, with an increase in kidney weight, proximal tubular nephrosis and cellular vacuolation (Perrin et …

    Hydroxy Propyl-Beta-Cyclodextrin Summary for IND / IRB .

    Hydroxy Propyl-Beta-Cyclodextrin Summary for IND / IRB Submissions 1) Chemistry and Manufacturing a) Chemistry . barrier examined various cyclodextrin derivatives for their toxicity and permeability. . in the kidney and lung and in dogs the highest concentration was in the kidney and liver.

    SPORANOX (itraconazole) INJECTION

    SPORANOX ® (itraconazole) Injection is a sterile pyrogen-free clear, colorless to slightly yellow solution for intravenous infusion. Each mL contains 10 mg of itraconazole, solubilized by hydroxypropyl-β-cyclodextrin (400 mg) as a molecular inclusion complex, with …

    Review of the Basic and Clinical Pharmacology of .

    Mild toxicity in the kidney and liver as a consequence of vacuolation occurred in rats at the maximum dose of 3000 mg/kg, which is approximately 50-fold greater than the SBECD dose typically .

    Effect of Cyclodextrin Infusion in a Rat Model of .

    Sulfobutylether-β-cyclodextrin (SBE-CD) is a pharmaceutical excipient known to bind verapamil. After intravenous administration, clearance of SBE-CD approximates glomerular filtration rate. We hypothesized that SBE-CD would complex with verapamil in vivo, enhance renal elimination, and increase time to death in a rat model of verapamil toxicity. Ten Wistar rats were allocated to control or …

    Review of the Basic and Clinical Pharmacology of .

    Review of the Basic and Clinical Pharmacology of Sulfobutylether-beta-Cyclodextrin (SBECD) . Mild toxicity in the kidney and liver as a consequence of vacuolation occurred in rats at the maximum .

    Cytotoxic Evaluation of Cisplatin, Cisplatin/Hydroxypropyl .

    Although Cisplatin is one of the most potent anticancer agents available for the treatment of solid tumors 4, its use is associated with serious side effects including renal toxicity, and late neurotoxicity as well as ototoxicity 5,6,7. 20% of patients receiving high-dose Cisplatin have severe renal dysfunction.

    Cytotoxic Evaluation of Cisplatin, Cisplatin/Hydroxypropyl .

    Biomedical and Pharmacology Journal (BPJ) is an international, open access, peer reviewed, quarterly research journal. Cytotoxic Evaluation of Cisplatin, Cisplatin/Hydroxypropyl- b-Cyclodextrin Complexes and their Nanoparticles Drug Delivery Systems. | Biomedical and Pharmacology Journal

    Potential Impact of Cyclodextrin-Containing Formulations .

    toxicity in vivo, it is not foolproof as not all the compounds with gastrointestinal toxicity in vivo are highly cytotoxic in vitro. For example, NSAIDs such as indomethacin, rofecoxib and flurbiprofen are not highly cytotoxic in vitro (CC. 50. values of > 0.2 mM); yet they cause gastrointestinal toxicity in vivo.

    Evaluation of intravenous voriconazole in patients with .

    SBECD is a second-generation cyclodextrin chemically-engineered not to accumulate in renal epithelial cells and thus avoid acute kidney injury. Despite limited evidence that SBECD has not been associated with renal impairment [ 10, 11 ], restrictions in its use in patients with estimated creatinine clearances (Cl cr ) less than or equal to 50 mL/min have been documented [ 12 ].

    Pharmacokinetics of sulfobutylether-β-cyclodextrin (SBECD .

    The disposition of sulfobutylether-β-cyclodextrin (SBECD), the solubilizing excipient in intravenous (IV) voriconazole, was assessed in seven male subjects with end-stage renal disease on hemodialysis and six subjects with normal renal function.

    Cyclodextrins - Valentino J. Stella, Quanren He, 2008

    Propylene glycol is a cardiac depressant and has shown renal toxicity (Levy et al., 1995), and the side effects of ethanol are well known. In an early unpublished study involving the use of SBE-β-CD to solubilize a potential drug candidate, an issue of its potential central nervous system (CNS) toxicity was raised after toxicity was seen with the drug candidate relative to a formulation in which the drug was …

    Therapeutic drug monitoring and safety of intravenous .

    Jun 21, 2016· Clinicians often avoid using intravenous voriconazole in patients with moderate to severe renal impairment [creatinine clearance (CrCl), <50 ml min −1] because they believe accumulation of the intravenous vehicle, cyclodextrin, may cause nephrotoxicity. 9, 10 However, recent studies have shown that a polysubstituted derivative of cyclodextrin used as an excipient for solubilisation of voriconazole, sulfobutylether‐beta‐cyclodextrin sodium (SBECD), does not accumulate in renal .

    Cyclodextrin Protects Podocytes in Diabetic Kidney Disease

    Diabetic kidney disease (DKD) remains the most common cause of end-stage kidney disease despite multifactorial intervention. We demonstrated that increased cholesterol in association with downregulation of ATP-binding cassette transporter ABCA1 occurs in normal human podocytes exposed to the sera of patients with type 1 diabetes and albuminuria (DKD+) when compared with diabetic patients with .

    cyclodextrin renal toxicity,

    Safety data on 19 vehicles for use in 1 month oral rodent .

    Safety data on 19 vehicles for use in 1 month oral rodent pre-clinical studies: administration of hydroxypropyl-ß-cyclodextrin causes renal toxicity: Safety data on vehicles for use in oral .

    cyclodextrin renal toxicity,

    Cyclodextrins in pharmaceutical formulations I: structure .

    lipophilic character. The polarity of the cavity has been estimated to be similar to that of an aqueous ethanolic solution. As a result of its molecular shape and structure, cyclodextrin exhibits theuniqueabilitytotrapaguestmoleculeinsideitscavity and act as a molecular container (Fig. 2).

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